Priority Research Program of the German Research Foundation (DFG)
SPP 1190 - THE TUMOR - VESSEL INTERFACE

SPP 1190 - Projects
 
A. Abdollahi / P. Huber/
J. Debus

A. Acker-Palmer
T. Acker
R. Adams
F. Alves
H. Augustin
H. Beck / M. Conrad
G. Breier / B. Wielockx
P. Friedl
C. Bruns / P. Nelson
B. Homey / A. Müller-Homey
Ch. Klein
V. Orian-Rousseau / H. Ponta
K.T. Preissner
B. Sipos
J. Sleeman
P. Vajkoczy
 

 

Prof. Dr. Jonathan Sleeman

 

Forschungsbereich Vaskuläre Biologie
Sektion für Mikrovaskuläre Biologie und Pathobiologie
Medical Faculty Mannheim, University of Heidelberg
Centre for Biomedicine and Medical Technology Mannheim (CBTM)

Ludolf-Krehl-Str. 13 - 17
D-68167 Mannheim, Germany
Phone: ++49 (0) 621 383 9955
Fax: ++49 (0) 621 383 9961

Lab Homepage

sleeman(at)medma.uni-heidelberg.de

 

 
Lymphangiogenesis and cancer
Discoidin Domain receptors (DDRs) activated by triple-helical collagens are found to be highly expressed in tumors. Based on previous studies and on our preliminary work we hypothesize that DDR1 and DDR2 play roles in cell-cell interactions and cellular migration during tumor progression. Our main goals are therefore (I) to define mechanisms by which DDR1 isoforms and DDR2 contribute to mammary tumor progression, (II) to explore cellular and molecular consequences of DDR1 overexpression in tumor cells, and (III) to define influences of the loss of DDRs in host-derived stroma on tumor progression and angiogenesis. The functions of DDRs on tumor growth, spread and tumor vessel formation will be analysed in these tumor mouse models by applying novel imaging techniques with contrast media and fluorescent labeled probes to study non-invasively tumor progression over time. Knowledge of the role of DDRs in the network of the multicompartment cell interactions within tumors will help to understand mechanisms that promote tumor invasion and metastatic dissemination.
 
- Relevant recent publications -

Bruyère, F., Melen-Lamalle, L., Blacher, S., Roland, G., Thiry, M., Moons, L., Frankenne, F., Carmeliet, P., Alitalo, K., Libert, C., ten Dijke, P., Sleeman, J. P., Foidart, J.-M. and Noël, A.: The lymphatic ring assay: A 3D culture system for the discovery of novel genes and mechanisms that regulate lymphangiogenesis. Nature Methods 5: 431-437, 2008.

Sleeman, J.P. and Neeb, A.: Tumor Lymphangiogenesis: What We Know and Don't Know. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites through the Lymphovascular System. Editor: Stanley P. L. Leong, M.D. Publisher: Springer. In press, 2008.

Sleeman, J.P. and  Cremers, N.: New concepts in breast cancer metastasis: tumor initiating cells and the microenvironment. Clinical and Experimental Metastasis 24: 707-715, 2007

Eccles, S., Paon, L. and Sleeman, J.P.: Lymphatic metastasis in breast cancer: importance and new insights into cellular and molecular mechanisms. Clinical and Experimental Metastasis 24: 619-636, 2007.

Berx, G., Raspé, E., Christofori, G., Thiery, J.P. and Sleeman, J.P.: Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer. Clinical and Experimental Metastasis, 24: 587-597, 2007.

Sleeman, J.P., (Fusenig, N. and Marmé, D, Eds): The relationship between tumors and the lymphatics: consequences for metastasis. In: Tumor Angiogenesis, , Springer Verlag, 2007.

Sleeman, J. P.:The relationship between tumors and the lymphatics: what more is there to know? Lymphology, 39: 62-68, 2006.

 

 

 

 

 

 
 
 
 
 
 

 

 
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Impressum | Last update: 06/26/2008