augustin(at)angiogenese.de

Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner KT, Vajkoczy P, Augustin HG: Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med 12: 235 - 239, 2006

Fiedler U, Christian S, Koidl S, Kerjaschki D, Emmett MS, Bates DO, Christofori G, Augustin HG: The sialomucin CD34 is a marker of tumor-associated lymphatic endothelial cells in human tumors. Am J Pathol, in press, 2006

Korff T, Dandekar G, Pfaff D, Füller T, Goettsch W, Morawietz H, Schaffner F, Augustin HG: Endothelial ephrinB2 is controlled by microenvironmental determinants and associates context dependently with CD31. Arterioscl Thromb Vasc Biol, in press, 2006

Nacak TG, Leptien K, Fellner D, Augustin HG, Kroll J: The BTB-kelch protein LZTR-1 is a novel trans-Golgi network protein and is degraded upon induction of apoptosis. J Biol Chem, in press, 2006

Heroult M, Schaffner F, Augustin HG: Eph receptor and ephrin ligand-mediated interactions during angiogenesis and tumor progression. Exp Cell Res, in press, 2006

Athanasopoulos AN, Economopoulou M, Orlova VV, Sobke A, Schneider D, Weber H, Augustin HG, Eming SA, Schubert U, Linn T, Nawroth PP, Hussain M, Hammes HP, Herrmann M, Preissner KT, Chavakis T: The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms. Blood, in press, 2006

Scharpfenecker M, Fiedler U, Reiss Y, Augustin HG: The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J Cell Sci 118: 771-80, 2005

Saharinen P, Kerkela K, Ekman N, Marron M, Brindle N, Lee GM, Augustin HG, Koh GY, Alitalo K: Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. J Cell Biol 169: 239-43, 2005

Müller SM, Terszowski G, Blum C, Haller C, Anquez V, Kuschert S, Carmeliet P, Augustin HG, Rodewald HR: Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture. Proc Natl Acad Sci USA 102: 10597-92, 2005

Martiny-Baron G, Korff T, Schaffner F, Esser N, Eggstein S, Marmé D, Augustin HG: Inhibition of tumor growth and angiogenesis by soluble EphB4. Neoplasia 6: 248-57, 2004

Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, Kriz W, Thurston G, Augustin HG: The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 103: 4150-56, 2004

Hegen A, Koidl S, Weindel K, Marme D, Augustin HG, Fiedler U: Expression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements. Arterioscler Thromb Vasc Biol 24: 1803-09, 2004

Korff T, Krauss T, Augustin HG: Three-dimensional spheroidal culture of cytotrophoblast cells mimics the phenotype and differentiation of cytotrophoblasts from normal and preeclamptic pregnancies. Exp Cell Res 297: 415-23, 2004

Augustin HG: Methods in Endothelial Cell Biology: A Lab Manual. Springer Verlag, 2004

Augustin HG: Translating angiogenesis research into the clinic: The challenges ahead. Br J Radiol 76: Suppl 1: S3-S10, 2004

Krauss T, Pauer U, Augustin HG: Prospective analysis of placenta growth factor (PlGF) concentrations in the plasma of women with normal pregnancy and pregnancies complicated by preeclampsia. Hypertens Pregnancy 22: 101-11, 2004

Goettsch W, Augustin HG, Morawietz H: Down-regulation of endothelial EphrinB2 expression by laminar shear stress. Endothelium 11: 259-65, 2004

Stahl A, Wenger A, Weber H, Stark GB, Augustin HG, Finkenzeller G: Bi-directional cell contact-dependent regulation of gene expression between endothelial cells and osteoblasts in a three-dimensional spheroidal coculture model. Biochem Biophys Res Commun 322: 684-92, 2004

Wenger A, Stahl A, Weber H, Finkenzeller G, Augustin HG, Stark GB, Kneser U: Modulation of in vitro angiogenesis in a three-dimensional spheroidal co-culture model for bone tissue engineering. Tissue Eng 10: 1536-47, 2004

Augustin HG, Reiss Y: EphB receptors and ephrinB ligands: regulators of vascular assembly and homeostasis. Cell Tissue Res 314: 25-31, 2003

Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marme D, Augustin HG: Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first IgG-like loop and the EGF-like repeats. J Biol Chem 278: 1721-27, 2003

Füller T, Korff T, Killian A, Dandekar G, Augustin HG: Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J Cell Sci 116: 2461-70, 2003

Veikkola T, Lohela M, Ikenberg K, Mäkinen T, Korff T, Saaristo A, Jeltsch M, Augustin HG, Alitalo K: Intrinsic versus microenviromental regulation of lymphatic endothelial cell phenotype and function. FASEB J 17: 2006-13, 2003

Piossek C, Thierauch KH, Schneider-Mergener J, Volkmer-Engert R, Bachmann MF, Korff T, Augustin HG, Germeroth L: Potent inhibition of angiogenesis by D,L-peptides derived from vascular endothelial growth factor receptor 2. Thromb Haemost 90: 501-10, 2003

Scheuffler KM, Drevs A, Von Velthoven V, Augustin HG, Reusch P, Klisch J, Zentner J, Marme D: Significance of VEGF, sFlt-1, and sTie-2 in plasma, serum, and CSF during cerebral ischemia. J Cereb Blood Flow Metab 23: 99-110, 2003

Augustin HG, Breier G: Angiogenesis: Molecular mechanisms and functional interactions. Thromb Haemost 89: 190-97, 2003