Priority Research Program of the German Research Foundation (DFG)
SPP 1190 - THE TUMOR - VESSEL INTERFACE

SPP 1190 - Projects
 
A. Abdollahi / P. Huber/
J. Debus

A. Acker-Palmer
T. Acker
R. Adams
F. Alves
H. Augustin
H. Beck / M. Conrad
G. Breier / B. Wielockx
P. Friedl
C. Bruns / P. Nelson
B. Homey / A. Müller-Homey
Ch. Klein
V. Orian-Rousseau / H. Ponta
K.T. Preissner
B. Sipos
J. Sleeman
P. Vajkoczy
   

 

Prof. Dr. Frauke Alves

 

Dept. of Hematology and Oncology
Georg-August-Univerity of Göttingen
Robert-Koch-Straße 40
D-37099 Göttingen, Germany
Tel: +49 (0) 551-39-8535
Fax: +49(0) 551-39-8587

Lab Homepage

falves(at)gwdg.de

 

 
Functional and anatomical monitoring of tumor progression by non-invasive imaging devices in various tumor models
Discoidin Domain receptors (DDRs) activated by triple-helical collagens are found to be highly expressed in tumors. Based on previous studies and on our preliminary work we hypothesize that DDR1 and DDR2 play roles in cell-cell interactions and cellular migration during tumor progression. Our main goals are therefore (I) to define mechanisms by which DDR1 isoforms and DDR2 contribute to mammary tumor progression, (II) to explore cellular and molecular consequences of DDR1 overexpression in tumor cells, and (III) to define influences of the loss of DDRs in host-derived stroma on tumor progression and angiogenesis. The functions of DDRs on tumor growth, spread and tumor vessel formation will be analysed in these tumor mouse models by applying novel imaging techniques with contrast media and fluorescent labeled probes to study non-invasively tumor progression over time. Knowledge of the role of DDRs in the network of the multicompartment cell interactions within tumors will help to understand mechanisms that promote tumor invasion and metastatic dissemination.
 
- Relevant recent publications -

Frauke Alves, Christian Dullin, Joanna Napp, Jeannine Missbach-Guentner Katharina Jannasch, Julia Mathejczyk, Luis A. Pardo,Walter Stühmer, Lutz-F. Tietze: Concept of a selective tumour therapy and its evaluation by near-infrared fluorescence imaging and flat-panel volume computed tomography in mice. Eur J Radiol (2009), doi:10.1016/j.ejrad.2009.01.048

Christian Dullin, María Zientkowska, Joanna Napp, Jeannine Missbach-Guentner, Hans-Willi Krell, Friedemann Müller, Eckhardt Grabbe, Lutz-F. Tietze, and Frauke Alves: Semiautomatic Landmark-Based Two-Dimensional— Three-Dimensional Image Fusion in Living Mice: Correlation of Near-Infrared Fluorescence Imaging of Cy5.5-Labeled Antibodies with Flat-Panel Volume Computed Tomography. Molecular Imaging, Vol 8, No 1 {January-February 2009): pp 2-Ï4

Jeannine Missbach-Guentner,y,z, Christian Dullin y, Marta Zientkowska, Melanie Domeyer-Missbach,
Sarah Kimmina, Silvia Obenauery, Fritz Kauerb, Walter Stu¨hmerz, Eckhardt Grabbey, Wolfgang F. Vogel and Frauke Alves: Flat-Panel Detector–Based Volume Computed Tomography: A Novel 3D Imaging Technique to Monitor Osteolytic Bone Lesions in a Mouse Tumor Metastasis Model. Neoplasia . Vol. 9, No. 9, September 2007, pp. 755 – 765

 

Christian Dullin, Jeannine Missbach-Guentner, Wolfgang F. Vogel, Eckhardt Grabbe, Frauke Alves:

Semi-Automatic Classification of Skeletal Morphology in Genetically Altered Mice Using Flat-Panel Volume Computed Tomography. PloS genetics 2007 July; 3(7): e118

Von Marschall Z, Scholz A, Stacker SA, Achen MG, Jackson DG, Alves F, Schirner M, Haberey M, Thierauch KH, Wiedenmann B, Rosewicz S: Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer. Int J Oncol 27: 669-79, 2005

Marten K, Alves F, Feuerstein T, Funke M, Engelke C, Tietze LF, Nebendahl K, Trümper L, Jakob C, Grabbe E: Multislice spiral computed tomography of an orthotopic severe combined immunodeficient mouse model for lung adenocarcinoma. J Exp Anim Sci 42: 181-91, 2003

Tietze LF, Feuerstein T, Fecher A, Haunert F, Panknin O, Borchers U, Schuberth I, Alves F: Proof of principle in the selective treatment of cancer by antibody directed enzyme prodrug therapy. The development of a highly potent prodrug. Angew Chem Int Ed 41: 759-61, 2002

Vogel W, Aszodi A, Alves F, Pawson T: Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development. Mol Cell Biol 21: 2906-17, 2001

Alves F, Saupe S, Ledwon M, Schaub F, Hiddemann W, Vogel W: Identification of two novel, kinase-deficient variants of Discoidin Domain receptor 1: differential expression in human colon cancer cell lines. FASEB J 15: 1321-23, 2001

Alves F, Borchers U, Padge B, Augustin H, Nebendahl K, Klöppel G, Tietze LF: Inhibitory effect of a matrix-metalloproteinase inhibitor on growth and spread of human pancreatic ductal adenocarcinoma evaluated in an orthotopic SCID-mouse model. Cancer Lett 165, 161-170, 2001

 

 

 
 
 
 
 
 

 

 
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Impressum | Last update: 04/21/2009